Hypobaric Hypoxia Induces Hypercoagulability Due to an Increase in Microparticles

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Point: Hypobaric hypoxia induces different physiological responses from normobaric hypoxia.

Hypoxia is defined as any combination of reduced barometric pressure (PB) and/or a reduced inspired fraction of oxygen (FIO2), which ultimately results in an inspired partial pressure of oxygen (PIO2) less than 150 mmHg (6). Pathophysiological responses to hypoxia or adaptations to hypoxic training can be investigated in two different types of exposure: hypobaric hypoxia (HH; FIO2 20.9%; PB 760...

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Point: Counterpoint: Hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia POINT: HYPOBARIC HYPOXIA INDUCES DIFFERENT PHYSIOLOGICAL RESPONSES FROM NORMOBARIC HYPOXIA

Hypoxia is defined as any combination of reduced barometric pressure (PB) and/or a reduced inspired fraction of oxygen (FIO2), which ultimately results in an inspired partial pressure of oxygen (PIO2) less than 150 mmHg (6). Pathophysiological responses to hypoxia or adaptations to hypoxic training can be investigated in two different types of exposure: hypobaric hypoxia (HH; FIO2 20.9%; PB 760...

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Membrane lipid diffusion and band 3 protein changes in human erythrocytes due to acute hypobaric hypoxia.

Because it has been reported that hypoxia in rats may promote lipid peroxidation and other free radical reactions that could modify membrane lipids and proteins, the effect of acute hypobaric hypoxia on human erythrocyte membranes was investigated. 12-(1-Pyrene)dodecanoic acid fluorescent probe was used to assess short-range lateral diffusion status in the membrane bilayer. Membrane protein mod...

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Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

Chronic exposure to hypobaric hypoxia (HH) causes memory impairment and prolonged state of mental confusion. However, effect of high altitude exposure on mood state and its underlying mechanisms have been poorly studied. Present study was undertaken to investigate the mood state alteration following chronic exposure to HH. Male Sprague Dawley rats were divided into five groups and exposed to hy...

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Last word on Point: Counterpoint: Hypobaric hypoxia induces different responses from normobaric hypoxia.

TO THE EDITOR: We thank the authors of the comments (see Ref. 1) who contributed their thoughts to this debate (3, 5). Many additional interesting arguments were provided, and most of the comments are in line with our view that hypobaric hypoxia induces different physiological responses from normobaric hypoxia but also that the underlying mechanisms and clinical/ practical relevance have not ye...

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ژورنال

عنوان ژورنال: Blood

سال: 2015

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v126.23.3549.3549